Recent Advances on Primary Sjogren's Syndrome and Depression Relationship

Abstract

Primary Sjogren's syndrome is a chronic autoimmune disorder that affects the exocrine glands, leading to dryness of the eyes, mouth, and other mucous membranes. Depression is a common comorbidity in patients with primary Sjogren's syndrome, and it can have a significant impact on patients' quality of life. This review paper provides an overview of the clinical presentation and prevalence of primary Sjogren's syndrome and depression, as well as a summary of the research progress on the relationship between these two conditions. The proposed mechanisms underlying the relationship between primary Sjogren's syndrome and depression, including neuroendocrine and immune system dysregulation, proinflammatory cytokines, stress and coping mechanisms, psychological factors, and other factors, are also discussed. Additionally, various treatment options for depression in patients with primary Sjogren's syndrome are reviewed, including pharmacological and non-pharmacological interventions. While there are some limitations to the current research, understanding the relationship between primary Sjogren's syndrome and depression is important for improving the care and quality of life of patients with this condition.